Wednesday, September 2, 2020
Health Profession Speaker number #3 Essay Essays -
Speaker name: Brian Reys Date: 02/21/2019 Speaker number #3 Profession: Genetic Counseling Visitor speaker, Brian Reys , presented the calling of Genetic Counseling. To start his introduction, Reys discloses to us bit by bit how to turn into a hereditary instructor just as all the suggestions and prerequisites expected to enter this field. Understudies should initially complete a four-year undergr aduate program and acquire a Bachelor's certificate in science based majors, for example, science, natural chemistry, hereditary, and brain research, and so on. Following are a few years of graduate program where understudies can procure their graduate degree in hereditary advising. As an alumni understudy, homework is bound to concentrate on a piece of general hereditary qualities and c linical hereditary qualities, just as brain science and psychosocial aptitudes . Moreover, fundamental logical and hereditary standards are likewise expected to assemble a general establishment for a vocation in this fi eld of calling. Subsequent to finishing all the coursework and preparing in t he program, understudies are required to take and breeze through a board test so as to get the ABGC and additionally CAGC confirmation. Mama jority of the schools would need understudies to have guiding or emergency intercession experience just as shadowing a hereditary advocate. On the off chance that shadowing is excessively troublesome, meeting hereditary advisors, either through telephone or face to face, about their calling in a phenomenal technique to fortify your involvement with this field. Furthermore , open work or helping individuals with incapacities, initiative experience, mentoring , chipping in, research , working in the medicinal services region, holding business, or simply being included and dynamic with exercises you are energetic about can b e useful encounters to have. One interesting point before entering this field is that p workmanship time graduate degrees or other adaptable participation alternatives are extraordinary. On the off chance that this is somethin g you are keen on, get some information about their adaptability or ability to do low maintenance program. Hereditary instructor is a medicinal services proficient with particular preparing in assessing and deciphering dangers of an acquired ailment. Hereditary guides work in specialist's workplaces, emergency clinics, hereditary testing labs, general wellbeing, research studies, and insurance agencies, and so on. They help individuals in a wide range of territories, for example, pediatrics, pre-birth, general, disease, and an assortment of claim to fame zones including nervous system science, cardiology, and digestion. Hereditary instructors likewise have a great deal of telephone discussions with patients to tell them of test results just as to see how they are getting along to catch up with them. They additionally work intimately with research centers to make sense of what tests the labs offer and the necessary kind of test. Hereditary guiding and testing can cost a ton of cash, in this manner, they invest a ton of energy in the telephone, for the benefit of their patients, with insura nce agencies to suggest for protection inclusion. Meticulous is one of the must-have abilities in light of the fact that hereditary advisors need to realize which tests are suitable for patients dependent on their own and family ancestries. In this manner, requesting the correct test for the correct patient is excessively imperative. Dynamic is additionally exceptionally significant in this calling in light of the fact that hereditary instructors assist patients with concluding how to explore and monitor their clinical consideration. These subjects can prompt passionate results and it relies upon the advisor to settle on a choice on how much data will be imparted to the patient. Notwithstanding that, hereditary advisors will be the individuals who offer passionate help to people and families. It is a clinical calling that requires generous preparing in both the logical and psychosocial factor of human services. There are not many professional successes accessible for hereditary advising including educator, open scholarly writer, lawmaking body and local gatherings' speaker, and so forth. In spite of the fact that there are not a great deal of profession openings accessible, hereditary guides can in any case be represented considerable authority in these three explicit center claims to fame: pre-birth, pediatrics, and disease. Greater part of the projects give the chance to consolidate or partake in strength facilities outside of or inside those three sub-classifications: cardiology, nervous system science or pediatrics claim to fame centers. So for what reason would one think about going into this field of calling? Many individuals, including me, are enthusiasm for hereditary qualities, yet need something more noteworthy and more close to home than just research center obligation. Others wish to be a piece of the clinical field yet think clinical
Saturday, August 22, 2020
The Island Armin Greder Essay Example
The Island Armin Greder Essay Armin Grederââ¬â¢s picture book The Island is a ground-breaking moral story that delineates dread of outsiders and numbness which parodies the majorityââ¬â¢s prohibition from the obscure and features the significance connections and imparts acknowledgment. The obstructions which forestall acknowledgment are shown in The Island generally through the distinctions of appearance. The islanders don't acknowledge the protagonistââ¬â¢s dissimilarities and his exclusion is appeared through the main twofold page. A little, powerless man stands bare and at last uncovered his defenselessness and whose confounded articulation connotes detachment to nature. The shortsighted workmanship shows how desolate the outsider is and the accentuation on the white proposes void. This is compared with the sarcastic picture on the following page, giving a feeling of personification of powerful, homogenous, judging, compromising men that uncover their monstrosity and congruity in a crude society. The incongruity of cultivating instruments being utilized as weapons as opposed to dealing with the land shows how xenophobic these individuals are and features the individualââ¬â¢s weakness and the quality the followers have massed against him because of the way that he is extraordinary. Basically, seeing the sarcastic and deriding differentiation of the two pictures we can see that distinction can't be acknowledged into a uninformed, homogenous culture. The result of being in a flat society and having the security of being in a gathering is that it can influence an individual and may darken their genuine beliefs. Explicitly when the angler made some noise and ââ¬Å"some individuals concurred with the angler however the others were louderâ⬠. This exhibits the voicelessness and defencelessness in our general public and shows how social constraint can make a setting where the individuals who are diverse are vilified, detached and abused. We will compose a custom exposition test on The Island Armin Greder explicitly for you for just $16.38 $13.9/page Request now We will compose a custom exposition test on The Island Armin Greder explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer We will compose a custom exposition test on The Island Armin Greder explicitly for you FOR ONLY $16.38 $13.9/page Recruit Writer The content exceptionally appears differently in relation to the pictures in this book and give a sarcastic, comical inclination. ââ¬Å"So they took him inâ⬠is compared with the islanders walking the man away with dangerous weapons and we see that the content is stating something positive while the pictures are negative. The utilization of ââ¬Å"theyâ⬠likewise connotates the traditionalist human progress, rather than utilizing a particular individual name, the individuals are characterized by a gathering. The evil cartoon of the cleric represents the villain and how foundations, for example, training, family, law and religion all show into concordant, the same perspectives. This is depicted when a mother cautions her kid about the man ââ¬Å"he will come and eat you in the event that you donââ¬â¢t finish your soup! â⬠The mention of the Big Bad Wolf and dangers in family life demonstrates the incongruity of a crude society that can't have an independent perspective. We can see that the network is pretentious to any supreme feelings and absence of character is clear. Thus, the parody and similarity in The Island makes us see the prohibition of an extraordinary person which results into bigotry and inconsideration of the other.
Friday, August 21, 2020
Nurse Shortage in Saudi Arabia Essay -- essays research papers
Presentation Foundation The Kingdom of Saudi Arabia has submitted tremendous assets by designating in excess of 13 percent of its yearly financial plan in improving the Kingdomââ¬â¢s clinical consideration framework, with a definitive objective of giving free clinical consideration to everybody. This responsibility has been meant in excess of 330 medical clinics worked by the legislature and the private part, with a limit of in excess of 50,000 beds. Of these clinics, 184 are controlled by the administration, with in excess of 16 thousand specialists, 40 thousand attendants, and in excess of 25 thousand colleague medical attendants as indicated by the Ministry of Health (2003). In view of these figures and the Saudi populace of 20 million individuals, to fulfill and keep up the present medicinal services standard, one out of each 200 Saudi nationals and inhabitants should work inside the Saudi clinical division. This number would exclude all other staff working inside the private clinical division or oth er faculty working off camera; where all administrative and strategic choices are being made. This errand of keeping up the present standard is hard, particularly at the nursing level. With a nation that has a youthful history, youthful training framework, and youthful populace with in excess of 50 percent of its residents younger than 18 years of age. With these realities, having enough medical caretakers is by all accounts an outlandish assignment to be accomplished. Different factors as long working hours and working night moves in a nation that is over defensive of its spouses and little girls are likewise factors that add to solidifying the errand. Because of these issues among others, Saudi Arabia has gotten one of the most medical caretaker bringing in nations on the planet, if not the most, with more than 80 percent of its attendants are non-Saudi nationals. The Shortage: To comprehend the Saudi deficiency in attendants, one needs to comprehend the Saudi reliance on outside medical caretakers. In a nation as youthful as Saudi Arabia; going from the innate age to the educational age in under 70 years was and still thought to be a fantasy worked out as expected for some individuals. With a low proficiency rates, 15 percent for men and under 2 percent for ladies in 1970, Saudi Arabia with its new undiscovered oil saved was submitted in creating and giving the best to its residents; schools, emergency clinics, networks, businesses, and occupations. As result, Saudi Arabia has concluded that it would import all methods and staff deprived to deliver a be... .... What's more, the Human Recourses Mangers should investigate improving the nursesââ¬â¢ expectation for everyday comforts by expanding Saudi medical caretakers pay. These choices can urge more Saudis to join the nursing field which would reflect in diminishing KAUH reliance on outside medical caretakers as more Saudis join the field. End Today, King Abdulaziz University Hospital is making some hard memories in giving quality consideration to its patients because of medical attendant lack that it the clinic is encountering. However, with some minor change inside the hospitalââ¬â¢s enrollment program, one can be guaranteed and sure that these projects would do what it intended to do. Until the enormous speculation that the Saudi Arabia is contributing inside the Saudi training framework pay, reliance on outside medical attendants would be a basic piece of the Saudi human services framework. References Mistory of Health, (2003), www.moh.com.sa. Polt, C. (2003), http://nursinghumor.com/nurse_forum/showflat.php/Cat/0/Number/3790/page/4/see/fallen/sb/9/o/all/fpart/1 Sadeeq, M., (2003), Nursing Jobs for Saudis, www.alwatan.com, Issue 2298. Sergeant, H., (2002), Labor's refuge approach is to trick the open that everything is great, Telegraph.co.uk,(Filed: 16/12/2002).
Tuesday, May 26, 2020
How to Gain Information From Critical Thinking Paper Writing Service?
How to Gain Information From Critical Thinking Paper Writing Service?Critical thinking paper writing service is one of the best decision that anyone can make in order to help them earn money online. You can also find a lot of advantages that you will be able to enjoy when you are using such an online business opportunity.These services provide the opportunity to use the internet as your mode of communication with other people and also to get the information that you need to help you start up an online business. It is important for you to gain knowledge about the business opportunities that you will be using in order to keep yourself updated with current business news. It is very important for you to use the services provided by the critical thinking paper writing service to help you make decisions that will help you earn money online.A critical thinking paper writing service will make it easy for you to gather the required information for an effective marketing campaign. You can have all the information about the industry that you are into so that you can quickly find out what other people are saying about the industry that you are involved in. The knowledge that you are gaining from the online service that you are using will allow you to set yourself apart from the rest of the competitors that you will be competing with in the business.A critical thinking paper writing service allows you to focus on the strengths of your product that you are selling. There is a great difference between a business and a hobby, and one of the greatest advantages that you will have is that you will not have to spend much time worrying about any of the things that you have to do in order to earn money. You can simply focus on your business and make money online.The internet has always been known for being the most inexpensive way of making money. With the help of critical thinking paper writing service you will be able to spend less time on advertisements that will attract visitor s to your website. The fact that you can spend less time on the advertisements means that you will have more time to focus on what it is that you are doing to make money online.The fact that you can use the critical thinking paper writing service in order to increase the traffic that you are getting to your website will allow you to get more visitors to your website. This will help you increase the amount of visitors that you are getting. The increasing the number of visitors that you are getting will allow you to earn more money and also help you attract more visitors to your website.You can use the critical thinking paper writing service in order to gain information about the latest market trends. You will be able to gain knowledge about how you can use this information to help you get more traffic to your website.
Saturday, May 16, 2020
The Food and Drug Adminstration from Upton Sinclairôs The...
The Jungle by Upton Sinclair was about Jurgis Rudkus who was an immigrarnt from Lithuania that came to the United States to discover his dreams, hopes, and desires. He took his family to Chicago to begin a new life. He worked in meatpacking industries that were unsanitary and brutal amount of hours that resulted into starvation. He was mistreated and realized the American dream wasnt as easy as it seemed. The book deals with disease, hunger, corruption, crime, poverty and death. ââ¬Å"Leave it to me; leave it to me. I will earn more money ââ¬â I will work harder.â⬠This was said by Jurgis frequently because him and Ona always struggled with money and having a job but Jurgis never wanted Ona to stress about those problems. Jurgis always took chargeâ⬠¦show more contentâ⬠¦Jurgis always struggled with money even when Ona was on the verge of dying. Jurgis finally convinced the women but Ona didnââ¬â¢t make it on time because it was too late already. Upton Sinclair sho ws you the struggle Jurgis went through with money and it wasnââ¬â¢t a fair life for him. When Jurgis lost both Ona and his son Antanas he was begging and a drunk man gave him a 100 dollar bill, that next day he enters a bar to receive change but the bartender tells him he has to buy a drink first, once he does the bartender only gives him 97 cents and refuses to give him his change. Jurgis then gets in a fist fight with him but then is sent to Jail. Once he was a prison he realized the life of crime was the best way to survive as an immigrant, then Jurgis finally loses his hope of getting that American dream he always wanted. Jurgis had a good reason to feel like this because he kept getting turned down by jobs and had nowhere to stay, he was homeless. The tittle of the book was misleading because I thought it was going to be about nature, but once you finish the book you realize itââ¬â¢s about surviving in the ââ¬Å"wildâ⬠. Survival in the United States isnââ¬â¢t easy especially when you are an immigrant. The author did achieve the books purpose because once the book was published the FDA had a new law on sanitation. The writing the author used was extremely effective because practically every chapter was about the struggles Jurgis is going through and
Wednesday, May 6, 2020
Mentoring Relationship Between Two Individuals, The...
Mentoring, in general, is a term used to describe a relationship between two individuals, the ââ¬Ëmentorââ¬â¢ and the ââ¬Ëmenteeââ¬â¢. In this relationship, the mentor with more knowledge supports and passes on knowledge to the mentee through teaching, guidance, and encouragement, thus empowering the mentee to make decisions based on his/her capabilities. According to Fouchà © Lunt (2010), in this relationship, it requires two parties to collaborate together to learn new things, allowing them to further their personal development and perform to their fullest potential. In mentoring session, client-centred skills are commonly used. For instance, being congruent and genuine. Mentor will have to demonstrates integrity and free from pretending someone who they are not. Furthermore, the mentor will have to accept the mentee as who they are and not pass judgement on him/her. Lastly, a mentor will have to be empathetic towards the mentee. This means that the mentor will have to put him or herself in the menteeââ¬â¢s shoes to understand and feel how the mentee feels. Stokes (2003) mentioned that, most of the skills used in mentoring are associated with client-centred skills. It gave the mentor to understand the point of view from the mentee rather from the mentor point of view. Planning In planning stage, there are different methods that the mentor has considered using to help mentee. Such as, rapport-building activities, setting ground rules, clarifying the roles, create S.M.A.R.T (Specific,Show MoreRelatedAn Overview of Mentoring1297 Words à |à 5 Pages Mentoring: An Overview Q1. An explanation that includes a definition of mentoring and at least 3 purposes Mentoring is defined as an informal transference of knowledge between an expert and a neophyte. The mentor is said to have greater knowledge either in a particular field or of general, human qualities that he or she wants to transfer to the mentee. (PowerPoint 1: Slide 3). The purposes of mentoring include supporting professional development within an organization; identifying and nurturingRead MoreMentor And Mentee Relationships From The Army1320 Words à |à 6 PagesMentor and Mentee Relationships in the Army Matthew P. Styles 24 October 2017 Abstract In this paper I will be discussing the dynamic and effects of the mentorship relationship in relation to the Army. I will accomplish this by using Army doctrine and personal experience. First I will explain mentorship as defined by the Army. I will then discuss the characteristics of a mentorship relationship. I will cover the basic principles to be used to define the relationship. Next I will discuss considerationsRead MoreMentoring - CIPD1253 Words à |à 6 PagesIntroduction ââ¬â About mentoring 3 2. Mentoring programmes 3 3. Conclusions and recommendations 5 4. References 5 Introduction Mentoring is to support and encourage people to manage their own learning in order that they may maximise their potential, develop their skills, improve their performance and become the person they want to be. Eric Parsloe, the Oxford School of Coaching Mentoring. Mentoring can have multipleRead More5dcm Essay1561 Words à |à 7 PagesCoaching and Mentoring within Organisations CIPD Membership Number 23141918 Introduction This report has been written to aid the development of coaching and mentoring within a leading banking and financial service company. As public sector organisations implement severe cuts and the private sector faces increased competition, all having to manage more with less, an increasing number of organisations are turning coaching and mentoring into theirRead MoreCompanies Must Mentor Relationships and Manage Conflicts Essay1172 Words à |à 5 Pagesand how it will undoubtingly affect the long-term success of your career. Understanding the five areas of the mentoring relationship becomes vital for all employees when effectively managing conflict. The next competency of leveraging diversity is just as important as being able to manage conflict. In leveraging diversity one must ââ¬Å"foster an inclusive workplace where diversity and individual differences are valued and leveraged to achieve the vision and mission of the organizationâ⬠. With the differencesRead MoreEssay Comparing Mentoring and Coaching1642 Words à |à 7 PagesComparing Mentoring and Coaching There are some key differences between mentoring and coaching. Mentoring- is known as the transfer of wisdom and has a protà ©gà © or mentee that takes an interest in their career path. The protà ©gà © is guided and advised by the mentor who has worn the same shoes and traveled the same path, usually someone older and wiser. The mentor guides, persuades, and encourages a person to reach their full potential in life, in a position in an organization or in a careerRead MoreSuccessfully Mentoring of Empolyees on the Growth of Diversity1144 Words à |à 5 Pagesdiversity within organizations has made it crucial for managers to mentor their employees as a ââ¬Å"tool to nurture and grow these individualâ⬠(Bailey Cervero, 2002). The Successful mentoring of these individuals also translates into positive outcomes for organizational initiatives. Nonetheless, the cultural characteristics of this diverse population has also made it harder to understand how to properly mentor these employees. Mentoring across cultures boundaries is an ââ¬Å"especially delicate dance thatRead MoreSchool Based Mentoring Programs ( Sbmp )919 Words à |à 4 PagesSchool-based mentoring programs (SBMP) have become widely used due to their presumptuously simple implementation and effective results; however, they remain to be scientifically under-developed and require integrity during implementation (Miller et al., 2013; Smith Stormont, 2011). Undoubtedly, SBMP have been shown to improve students: attitudes, confidence, school engagement, school performance, behaviour, vocational skills, and emotional and social skills (Converse Lignugaris/Kraft, 2009; MillerRead MoreMentoring in the Workplace2337 Words à |à 10 Pagesbusiness executives may say that earlier in their career they established a mentor relationship that helped them to get to where they are in their career. Research has shown that this statement can be true for some executives but not for all. Some experts believe that just having mentor relationships can or cannot affect someoneââ¬â¢s career path and development. The purpose of this paper is to explain exactly what mentoring is and how it successful works within the workplace environment. Using supportRead MoreHow Coaching and Mentoring Help Employees and Students Succeed1352 Words à |à 6 PagesCoaching and Mentoring Vital to Success Dineace D Minnick Colorado Technical University Coaching and Mentoring Vital to Success In my opinion I feel that to be successful you truly need to line up people around you who are will to Coach and Mentor you. It also looks good for you to be seen as a Coach and Mentor. I see this as an excellent way to always have feedback and direction to help reach goals and succeed to levels of excellence. I chose this topic because my ultimate goal, within
Tuesday, May 5, 2020
Sylvia Plath Theme of Honesty free essay sample
D. Salingerââ¬â¢s character ââ¬ËHolden Caulfieldââ¬â¢ in ââ¬ËCatcher in the Ryeââ¬â¢. Both characters have a cynical tendency to constantly reveal their inner most opinions about the society around them, discussing their feelings about personalities and appearances. Plath and Salinger were both born in the early twentieth century, despite this had completely opposing backgrounds and upbringings. Plath experienced a quiet and subtle early life in Winthrop Massachusetts, a small seaport town. Whereas Salinger endured a mainstream, fast paced and fashionable beginning in the city of New York. Both these places can make a person incredibly sociable or utterly isolated. Emily Dickinsonââ¬â¢s ââ¬ËSelected Poemsââ¬â¢ also reveals honesty and she confesses her depression very openly and concisely. Being born in the nineteenth century, Dickinson often expresses her opinions of the social placement of women and their restricted lives. She is unlike the ââ¬Ëstereotypical womanââ¬â¢ of her era, and retaliates in her writing against the inequalities between the sexes. Many critics believe her to be a feminist. Throughout the ââ¬ËComing of ageââ¬â¢ novel ââ¬ËThe Bell Jarââ¬â¢, Greenwood, the protagonist narrator, is constantly breaking down situations, people and objects around her, like saliva to food. She over analyses the nature of society all around her, and enjoys criticising. When Greenwood first introduces the reader to ââ¬ËDoreenââ¬â¢, the mischievous opposite to Greenwood, she contradicts her description beginning with ââ¬ËI guess one of my troubles was Doreenââ¬â¢. This statement makes the reader begin to build a negative, unpleasant personality in their minds. However she concludes her escription with ââ¬Ëa mysterious sneer, as if all the people around her were pretty silly and she could tell some good jokes on them if she wanted toââ¬â¢. This statement shows a clear admiration for Doreen, differing from the initial introduction, however also shows Esther expressing her opinion of Doreen being a mean kind of person, but likes that about her. This cou ld be considered to be a hidden metaphor, for Greenwoodââ¬â¢s slow decent into depression and madness, beginning with confusion and uncertainty, typical signs of insanity, which reflects the rest of her story. This is an upfront and honest introduction to the novel. This shows a friendship between the two characters, but a kind that is of a girlish jealous nature. Greenwood clearly admires Doreenââ¬â¢s personality but envies her social power at the same time. Plath also reveals Greenwoodââ¬â¢s detachment and alienation from others throughout the novel, isolating her character. This could be to remind the reader of her insane self compared to the sane society and people around her. This can be explained through Greenwood stating ââ¬ËI felt myself shrinking to a small black dot against all those red and white rugs, and that pine-panelling. I felt like a hole in the groundââ¬â¢, in this short description of her feelings, she shows vast indications of isolation and depression. The use of the words ââ¬Ëshrinkingââ¬â¢ and ââ¬Ësmallââ¬â¢ reflect her feelings of disappearing and becoming non-existent to the world. Also, describing herself as ââ¬Ëblackââ¬â¢ compared to the ââ¬Ëred and white rugsââ¬â¢ is a use of juxtaposition in the colours, which show how uninteresting she finds herself, being dull and dark in comparison to the bright vibrant rugs, which could imply the rest of society around her. This identification of herself could be considered an honest view of how others perceive her. Another character that is slated by Estherââ¬â¢s criticism is Dr. Gordon. She belittles him by saying ââ¬ËHow could this Dr. Gordon help me anyway? With his beautiful wife, and his beautiful children, and his beautiful dog, haloing him like a Christmas cardââ¬â¢. Dr. Gordon is the psychiatrist who made a mistake during Estherââ¬â¢s electroshock therapy in a terrible way. As the patriarch of the ideal American family, Dr. Gordon seems to represent American society, punishing Esther for going against social expectations, rejecting marriage and family. This shows her honesty and awareness of her social differences and views with the rest of society, and is mocking them for being so stereotypical. Her repetition of the word ââ¬Ëandââ¬â¢ reminds the reader of a list, almost as though Esther is expressing that there are endless differences between society and herself. J. D. Salinger uses the character of Holden Caulfield in parallel with Plathââ¬â¢s character Greenwood, a first person, and protagonist narrator. Holden also suffers with the illness of contradiction, alongside insanity of course, this is another similarity the two characters share. The reader is introduced to an upfront, confident Holden, whom from the setting of the novel, is obviously tense with the topic of family, and starts by stating ââ¬ËI donââ¬â¢t feel like going into all of itââ¬â¢, then continues to ââ¬Ëgo into it allââ¬â¢ by describe how annoyed his parents would be if he disclosed any personal information, ââ¬ËEspecially my fatherââ¬â¢. He is building a personality of his father without realizing, showing a particular conflict with his father, more so than other members of the family. He is also separating himself from his family in that he would openly discuss their issues, whereas his family would not. Essentially, the readers receive an immediate separation and self alienation from his family, and recognise Holdenââ¬â¢s critical personality from the start. It is clear that throughout ââ¬ËThe Bell Jarââ¬â¢, the character of Esther is used by Plath to explore the theme of sexuality, and the effect the 1950ââ¬â¢s attitude towards sex had on the women of that time. ââ¬ËThen he just stood there in front of me and I kept staring at him. The only thing I could think of was turkey neck and turkey gizzards and I felt very depressed. This description of Buddyââ¬â¢s penis does not only reveal Estherââ¬â¢s criticisms of other further, but we begin to see her real attitude towards sex and Buddy himself. The general theme between Esther and Buddy is that of sexual tension and virginity, however, although Esther is supposed to be ââ¬Ëin loveââ¬â¢ with buddy, itââ¬â¢s quite clear that she is not attracted to him and is not very fond of him altogether, we see this at the point where she is supposed to be at her most happy or intimate, when Buddy becomes naked in front of her, she feels ââ¬Ëvery depressedââ¬â¢. This may not be completely down to the appearance of Buddyââ¬â¢s private parts, but may be Estherââ¬â¢s attitude towards sex altogether, that she is only so eager to lose her virginity because it was the social norm, and wanted to be ââ¬Ëpart of a great traditionââ¬â¢. Esther shows her honest view upon societies attitude towards sex and its sexist inequalities towards sex when she says ââ¬ËI couldnââ¬â¢t stand the idea of a woman having to have a single pure life and a man being able to have a double life, one pure one not. ââ¬â¢ Plath is trying to portray through Esther her rebellious opinions towards sexual inequalities between men and women. In the novel, Esther discovers that sexuality is divorced from any expression of love and passion. Sex for women is only a necessity within marriage to have children, and has no relevance with romance or intimacy, Esther could be showing the reader her honest feelings of wanting to have a double life like the men of her era, and be able to experience sexual encounters out of passion and love, no just for starting a family, without being judged. However could also be suggesting her view that all people should remain celibate until marriage, both men and women, but on both interpretations, she is yearning for equality amongst the sexes. With Emily Dickinsonââ¬â¢s unconventional style of writing and rebellious grammar, it is not a surprise that her poems do not meet the same literacy concepts as Plath and Salinger. Her poem ââ¬ËA Narrow fellow In the Grassââ¬â¢ reflects her individuality and opposing touch of honesty towards sexuality in every stanza. The literal and logical interpretation for the poem is her longing to see a snake in the grass, but only being able to glance at sections of the snake. However, Luann Suhr claims that the poem ââ¬Ëis in fact about the fear a virgin has towards sexââ¬â¢. This differs from Plath and Salingerââ¬â¢s habit of blurting constant criticism of others, and shows a clear self aggravation and criticism. There are many literary devices used to allude to its sexual theme. Dickinson shows the fear of a virgin by knowing the naturalness of sex yet still being afraid of it. This is accomplished through the literary devices of personification, metaphor, and visual imagery. In the first line of the first stanza, by using the word ââ¬Å"fellowâ⬠in her description of the snake she alludes to the snake in regards to man. In colloquial terms, the word snake is often used with regards to male genitalia. A ââ¬Å"narrow fellowâ⬠can therefore be read as the male penis. This could also relate to her opinion of men being sneaky like snakes towards the concept of sex, compared to the expectations of a woman to remain celibate, showing her honest neglect of the sexist attitude that society has to sexuality. The second stanza ââ¬ËThe grass divides as with a comb- Aspotted shaft is seen- And then it closes at your feet and opens further onââ¬â¢ Dickinson has purposely used opposing adjectives to represent her curiosity about sex, how one moment she is captivated by the idea of losing her virginity, then the next her mind closesââ¬â¢ her imagination because she knows she must remain celibate until marriage. It could also represent a previous sexual encounter that was never fulfilled, she is giving the reader an insight into her mind and how ââ¬Ëdividingââ¬â¢ her mind like this could cause her mental illness to thrive. Once she has captured a small snippet of understandin g ââ¬ËAspotted shaftââ¬â¢, her sub conscious ââ¬Ëclosesââ¬â¢ her out. Dickinsonââ¬â¢s confusion is clear, it sounds almost as though she is at war with herself, insanity, society and again differs from Plath and Salinger in that she does not alienate herself from society, but from her own emotions and desires. Despite this, she carries on fantasizing about this sexual encounter by saying ââ¬Å"sudden isâ⬠Dickinson is stating that this male is quick to ejaculate. This can be further proved by the line before which says, ââ¬Å"you may have met himâ⬠. The word ââ¬Å"metâ⬠can be referring to the sexual meeting, and therefore puts a sexual connotation to the next line. When Dickinson reaches for this thing that scares her so much, it disappears. In the end of stanza four, she says, ââ¬Å"it wrinkled, and was goneâ⬠. This is the visual imagery of a penis becoming flaccid. This man she is describing may represent her constant need to please, and fit in. Her honest desperation to communicate her frame of mind seeps through, when the reader finishes the poem to discover, that not even in the final stanza, does she reveal the root of the poem or what its meaning is, leaving readers to feel her confusion, to have a sense of what it would be like to suffer from mental illness, not knowing why or understanding the thoughts she has. Her complete sincerity leaves the reader, in a state of confusion, reflecting her everyday agenda. An aspect of honesty which can be related to all three authors is the honesty with the self and self reflection. Sylvia Plath uses the character of Esther Greenwood to portray her own personal attributes that she struggled to express in reality. We see this when greenwood describes her drink as ââ¬Ëwet an depressingââ¬â¢, the very statement that a drink is depressing shows how irritating her character is, in the sense that she complains and reverts anything and everything she sees or touches to seem as depressing as she is. This could be Plath expressing through Greenwood that she is irritated by herself and her own character, the illness is not only discovered, but it irritates her, revealing a full acknowledgement of its existence. This honest analysis in itself portrays that Greenwood sees herself as an irritation to society and this could explain her isolated behaviour, a fear of not being accepted. Another self reflective part of the novel is stage in which Esther begins to lose touch with herself worth, ââ¬ËI started adding up all the things I couldnââ¬â¢t doââ¬â¢ I felt inadequateââ¬â¢. Up until the summer before Estherââ¬â¢s senior year, she had done a good job at being a student of literature. However the thought of entering the real world terrifies her. The world she lives in seems to have no place for the literary ideals that she cherishes, which of course is her being pessimistic. This could be forcing her to doubt herself, and self worth towards the world, which may represent Plath attempting to portray Esther as feeling worthless and useless. Or, another view could be that Esther sees herself as being too complex and misunderstood for the simple minds and dreams of the typical American girl of that era. Emily Dickinson shows honesty with the self and self reflection in the poem ââ¬ËThe soul has Bandaged momentsââ¬â¢ which explores through symbolism, an internalised spiritual and psychological state of experiences of the soul. Which is personified as a woman, and some may interoperate the personification to be Dickinson herself. In the first stanza it says ââ¬ËThe soul has bandaged momentsââ¬â¢ which shows a physical and abstract outlook and insight of the soul. It also implies injury and pain that could metaphorically mean that the soul being personified as Dickinson, she is hurt by her mental illness and attempts to heal herself when ââ¬Ëshe feels some ghastly fright come up to stop and look at herââ¬â¢. This could represent her soul searching and not being fond of what she finds in her mind, or it could alternatively represent her mental illness of depression creeping up on her, it has a sinister feel and may be considered that the mental illness is trespassing, on the privacy of her soul and self. She views this as a form of psychological assault and molester by using words in stanza two such as, ââ¬Ëcaressââ¬â¢ and ââ¬Ëhovered-oââ¬â¢erââ¬â¢. These bring feelings of uncomfortability and helplessness to the reader. Dickinson is trying to express the mercilessness of insanity. This shows Dickinsonââ¬â¢s fear of herself and her capability, some may view it as a panic towards her ever-growing stronger insanity and her ever-growing weaker free will against is. To conclude, a critic once claimed that ââ¬ËWriters, who suffer with mental illness, are likely to revolve their writing around complete honesty of their mind. Which, in a sense, creates more emotional and believable connections with the reader, making the insanity seem normal, and allow the reader to feel an attachment with the authorââ¬â¢, some may consider this statement to be complete nonsense, however, the analytical evidence shows that there may be some truth in this observation. One may find the ability for Plath, Dickinson and Salinger, all of different era and lifestyle, to have managed to create such personalities and mind wondering scenarios with just the use of a single concept of honesty to be greatly admired.
Wednesday, April 15, 2020
Discovery to Debacle Essay Example
Discovery to Debacle Essay Introduction: The outgrowth of the monoclonal antibodies as regulative T cell activators raised a great ardor among research workers to develop them as potent go-betweens for immunotherapy. Although many of these monoclonal antibodies have been marketed for the intervention of assorted diseases [ 1 ] ( Bhogal, 2007 ) , some of them were unable to make this finish due to their discontinuance in the clinical phases. One such model theoretical account is TGN1412. TGN1412 is an IgG4 type of monoclonal antibody which acts as superagonist for CD28, a co-stimulatory receptor required for T-cell activation. Since TGN1412 activates the T cell without anterior activation of the T cell antigen ( TCR ) receptor it was designated as a superagonist [ 2 ] ( Bhogal, 2006 ) . However, the vision of using TGN1412 as an anti-inflammatory agent was crashed when it failed in the first measure of the clinical surveies. The stage 1 clinical test of this promising drug emerged to be a catastrophe taking to dangerous effects in the voluntaries. This reappraisal focuses on the find, presymptomatic development and ethical concerns related to the drug and the possible mistakes made during the period from its find to the ruin. All the above factors had a cascading consequence and contributed greatly to the drug s failure. This fiasco of TGN1412 demands the important change in the current drug testing form for the advancement of the hereafter development of drugs. Development: -To promote the activation of immunosuppressive regulative T-cells, TeGenero, a German Pharmaceutical company developed TGN1412, a wholly humanized monoclonal antibody by protein technology of the non-human species generated antibody ( mice antibody ) to obtain belongingss specific to worlds. Protein technology involved the transportation of the complementary determining parts of a mouse anti-human CD28 ( 5.11.A1 ) antibody into human antibody concatenation proteins derived from Chinese hamster ovary ( CHO ) cells [ 1 ] ( Bhogal, 2007 ) . Autoreactive T-cells doing redness and autoimmunity against certain cells and organic structure tissues are kept in changeless cheque by regulative T cells. Normal T cell activation requires both the T cell receptor and CD28, a receptor protein on surface of T cells for its proliferation and activation [ 3 ] ( Vitetta, 2006 ) . Harmonizing to surveies conducted by TeGenero, TGN1412 can trip the T cells of all specificities and release c ytokines by aiming an antigenic determinant of CD28, a extremely conserved part of CD cringle which is exposed on the extracellular surface of T-cell membranes, therefore short-circuiting the demand to T cell receptor specificity. With this hope of stamp downing the immune system by activation of regulative T cells, TGN1412 was developed as a fresh therapy for autoimmune and inflammatory diseases. In Rheumatoid Arthritis, an autoimmune disease, TGN1412 reduced the degrees of inflammatory go-betweens by activation of the T-cells. B-CLL, most common type of chronic leukaemia is associated with a high white blood cell count and slow accretion of a peculiar type of B-cell. TGN1412 is effectual in intervention of B-CLL by non merely triping and exciting the growing of lymph cells but besides heightening the antigen showing ability of B-cells associated with the B-CLL. [ 2 ] ( Bhogal, 2006 ) We will write a custom essay sample on Discovery to Debacle specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Discovery to Debacle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Discovery to Debacle specifically for you FOR ONLY $16.38 $13.9/page Hire Writer After complete development, pre-clinical and carnal testing, TeGenero decided to continue with first in human clinical test to measure the safety, tolerability and pharmacokinetics of TGN1412 and supervise its immunogenicity and effects on T cells, B cells and on cytokine degrees in blood serum. For this intent TeGenero recruited Parexel, a separate clinical test unit. The test protocol submitted by Parexel was authorized by Medical wellness regulative bureau ( MHRA ) on 27th January 2006 approved by Medical Ethics commission on 14th February 2006. [ 2 ] ( Bhogal, 2006 ) Phase 1 Clinical test failure: Harmonizing to the test protocol designed, on 13 March 2006, the first group of 6 voluntaries received a dosage of 0.1mg/kg on and was scheduled to have farther escalating doses over three-week period. However, the test turned ruinous and had to be suspended when these voluntaries developed cytokine release syndrome with an unmanageable addition in tissue cytokine concentrations finally taking to multiple organ failure. [ 4 ] ( Schraven, 2008 ) Preclinical: The probe conducted by MHRA and the European governments after the clinical test stated that there were no mistakes in fabrication, preparation and no marks of taint in the batch TGN1412 administered to the voluntaries [ 4 ] ( Schraven,2008 ) . With the purpose of forestalling such fatal events in future, the expert groups were recruited by Secretary of the province for wellness to look into the mistakes taking to failure of the test. The presymptomatic surveies with regard to the species choice, invitro and exvivo testing, appropriate dose choice and carnal surveies were points subjected to re-examination. In-vitro testing: Sing the species choice, non human Primatess are most frequently considered for the presymptomatic testing due to their close familial and pharmacological similarity to worlds. In instance of TGN1412, Rhesus macaques and the cynomolgus monkeys were used as the theoretical account for surveies on the footing that the 6 amino acid epitope on the C D loop of CD28 to which the drug appears to adhere is wholly similar and conserved in both the macaques and the worlds. [ 5 ] ( Stebbings, 2009 ) After careful designing of the TGN1412 based on the conserved sequence of the non-human Primatess, it could place the recombinant human cells showing CD28 with high adhering affinity. Specificity of TGN1412 for CD28 was confirmed with adhering surveies on the human cells showing CD-28, Cytotoxic T lymphocyte antigen-4 ( CTLA-4 ) and the inducible co-stimulator ( ICOS ) , in which TGN1412 did non expose cross-reactivity with the CTLA-4 and ICOS with the fact that both these proteins have high grade of amino-acid sequence homology with CD28. In order to further synergize the species selectivity, adhering ability of TGN1412 in the human, Macaca mulatta and cynomolgus monkeys and gnawers and marmoset T-cells was evaluated. It was found that nanomolar concentration of TGN1412 could adhere specifically to human and Macaca mulatta and cynomolgus monkeys but non with marmoset and rodent T-Cells due to difference in the antigenic determinant of the marmoset and human CD28. In marmoset species , 2 of the amino acids out of 6 differ as compared to rat in which all 6 amino acids are different, therefore impacting the binding of the TGN1412 to CD28 of these species. All these surveies prompted the research workers to continue with the surveies on the Macaca mulatta and cynomolgus macaques. [ 1 ] [ 2 ] ( Bhogal, 2006, 2007 ) Along with pre-dominant look in human lien, CD28 is besides expressed in the lymphatic, respiratory, connective and female generative tissues. Even though being cognizant of this fact, the cross-reactivity surveies in cynomolgus monkeys were performed with limited tissues non accounting for complete tissue distribution of TGN1412. In add-on to this, cross-reactivity was observed with the respiratory CD28 which was unexplained in the redirect examination of presymptomatic trials since respiratory disfunction was observed in the voluntaries who participated in the test. [ 2 ] ( Bhogal, 2006 ) . Thus it was suggested that executing such surveies with wider assortment of tissues would greatly assist in the hereafter development of immunobiologics. In add-on to binding and the cross responsiveness surveies, invitro trials with human peripheral blood mononuclear cells ( PBMC ) were performed for foretelling the invivo specificity and the species sensitiveness for TGN1412 [ 5 ] ( Stebbings, 2009 ) . Since most maps of the antibodies are mediated by adhering of their Fc part to Fc receptor incorporating cells [ 4 ] ( Schraven,2008 ) , in-vitro trials finding specificity, with Fc immobilized TGN1412, which mimicked the Fc binding were performed in cynomolgus monkeys and adult male, due to high grade of similarity in their sequence homology of the Fc receptor. It displayed that TGN1412 could arouse the response merely when it was immobilized onto a surface, or coupled via immobilized Fc-specific antibody. In contrast to the above consequences, immobilisation of TGN1412 in the cynomolgus monkeys did non demo its action as a superagonist [ 5 ] ( Stebbings, 2009 ) . Alternatively it acts as conventional CD28 agonist necessitating T-cel l receptor and CD28 activation for T cell stimulation and above all that it did non trip the cytokine production as seen in the voluntaries in the clinical tests [ 2 ] ( Bhogal, 2006 ) . All these consequences indicated hapless species choice for the presymptomatic trials. Animal Trials: Pharmacokinetic and toxicological issues have been taken into consideration in correspondence with carnal surveies. Pharmacokinetic appraisals made during the comparative survey of the TGN1412 with its variant TGN1112 in Macaca mulatta macaques, indicated that after their IV disposal, both the drugs were present in the blood serum for 20 yearss, with the peak concentration of the T-cells and no indicant of the increased cytokine degrees. Due to the overestimate of these effects in invitro surveies, 28 twenty-four hours surveies were performed in the cynomolgus monkeys. The half life of TGN1412 in these surveies was found to be 8 yearss with ascertained addition in the expansion of the lymph nodes and enlargement of the CD4+ T-cells. Furthermore, 50mg/kg was set as the no-observed-adverse consequence degree ( NOAEL ) even though these surveies indicated 5mg/kg as an optimum dosage for TGN1412. With respects to the 28 twenty-four hours toxicologic surveies conducted in the cynomolgus monkeys, there was no indicant of the drug related toxicity and half life was similar to the pharmacokinetic trials. All the above consequences supported TeGenero in continuing with the clinical tests in homo for proving the safety and efficaciousness of the drug. [ 2 ] ( Bhogal, 2006 ) Methodological and Ethical concerns: -The calamity of the TGN1412 alerted the field of immunotherapeutics, to non merely meticulously study presymptomatic trials but besides safeguard the ethical regulations associated with each procedure in drug development. Sing the methodological concern, the disposal of appropriate dosage is really important. The dosage of 50mg/kg of TGN1412 for the disposal into the voluntaries was selected on footing of no-observed-adverse consequence degree ( NOAEL ) which was a high dosage [ 5 ] ( Stebbings, 2009 ) . However, the dosage selected should be of optimum concentration, optimum signifies that it should be low plenty to protect the safety of the voluntaries and high plenty to arouse the response for which it is tested. Thus the choice of the dosage should be based on use of all relevant information known about the drug including the freshness, species specificity and mark distribution, in vivo dose response curve and receptor tenancy with regard to concentration. From the invivo dose response curve obtained from the surveies on the Human PBMC, bell shaped dose response curve was obtained with optimal responses between 2-10ug/ml. These consequences stated that the dosage should be selected from the scope of doses falling within this curve and implied the usage of MABEL ( minimal anticipated biological consequence degree ) attack for choosing the safe and optimum dosage for the tests [ 5 ] ( Stebbings, 2009 ) . Second, the design of TGN1412 test required the disposal of the drug to six voluntaries within short clip continuance of two proceedingss. Since monoclonal antibodies have fresh mechanism of action, disposal into fewer voluntaries with sufficient clip intervals is recommended. A better method would be detecting the consequence of such drug in one voluntary before continuing with the test. A good pattern of documenting the medical history of voluntary was non followed in the instance of TGN1412 by the test carry oning grou p, Parexel. [ 6 ] ( Ferguson, 2009 ) Sing the ethical issues, each test performed must be in concurrency with the Helsinki s declarations to safeguard the rights and safety of each take parting voluntary. Conversely all take parting groups including the voluntaries and the research groups must follow the ethical guidelines. The inside informations of the approved survey by the Ethics commission must be given to the voluntaries. Consent signifier must be short, concise and comprehensive and each voluntary should be given adequate clip to analyze and do determination sing take parting in the test. In instance of any inauspicious events, the test groups must describe it instantly to the moralss commission to avoid put on the lining the life of participants. In instance of TGN1412 each voluntary was given a big amount of money as compared to other stage 1 tests. In add-on, the clip given to analyze the long consent signifier was limited [ 6 ] ( Ferguson, 2009 ) . Therefore, attention should be taken that none of the regulat ions are breached under any fortunes. The chief aim of the investigational survey on failure of TGN1412 was to better the drug development procedure and cut down its clinical failure. However, even after this catastrophe in 2006, many of the late developed drugs have undergone failure. Taranabant ( MK-0364 ) was developed by Merck A ; Co. for intervention of fleshiness, which is frequently associated with increased hazard of developing cardiovascular diseases, diabetes and malignant neoplastic disease [ 8 ] . Taranabant is a fresh reverse agonist of cannabinoid-1 receptors ( CB1R ) , which are of import in ordinance of organic structure weight, energy usage and lipid and glucose metamorphosis [ 9 ] ( Pacher, 2009 ) . The thought of cannabinoid exciting appetency was based on utmost hungriness experienced by hemp tobacco users [ 8 ] . This observation led to the birth of Taranabant which stimulates weight loss by adhering to cannabinoid receptors and forestalling their activation. The presymptomatic surveies indicated th at acute disposal of Taranabant inhibited the food-intake and weight addition in dose dependent form, therefore taking to weight loss and lessening in organic structure fats which were non observed in smasher mice deficient in the CB1R cistron. Based on these surveies it was found that merely 30-40 % CB1 receptor tenancy was required to advance weight loss. These consequences from presymptomatic surveies inspired the research workers to continue with clinical tests. The first clinical survey was carried out in 24 healthy voluntaries as random, double-blind and placebo controlled test. This survey was successful as it displayed additive and dose dependent addition in AUC0 and Cmax values, long half life of 38 to 69 hours and mild inauspicious events [ 10 ] ( Addy, 2008 ) . Phase II test carried out for 12 hebdomads in 533 patients confirmed that effectivity of Taranabant in bring oning weight loss as compared to the placebo. Phase III test was initiated in 2400 patients and was inten ded to be continued for 2 old ages. Even after 1 twelvemonth of stage III survey in March 2008, Taranabant was found effectual in cut downing dual sum of weight by dosage of 2mg of drug with combination of exercising and diet. However, in October 2008 it was withdrawn due to GI and CNS side effects associated with it. [ 8 ] ( www.drugdevelopment-technology.com ) . Gastrointestinal side effects associated were chiefly sickness, purging concern, drowsiness abdominal uncomfortableness, and increased intestine motion. Other drug associated symptoms observed were mood alteration, fatigue and increased sudating [ 9 ] ( Addy, 2008 ) . Happening of all these inauspicious events compels the research workers to retreat a specific drug from the clinical test. Many other drugs which appeared to be innovators in development of assorted diseases have faced the failure during their clinical testing continuance either due to their toxic effects in worlds or due to unsatisfactory degree of consequence for intervention of the disease. Flurizan ( tarenflurbil ) , developed by Myriad Pharmaceuticals was intended for the intervention of Alzheimer s disease by selective take downing the Amyloid degrees. However, it was withdrawn from Phase III clinical test since it was found to be unproductive in bettering the cognitive signals and everyday activities in Alzheimer s disease patients. [ 11 ] ( www.drugdevelopment-technology.com ) Decision: Since monoclonal antibodies have evolved to be one of the promising drugs in intervention of countless diseases owing to their novel mechanism, a argus-eyed reappraisal of the presymptomatic surveies before their disposal into worlds is critical. The presymptomatic surveies of the antibody based drugs should be performed in Primatess possessing wholly matched antigenic site with that in worlds. Apart from the detailed the analysis of the presymptomatic consequences and appropriate species choice, it is important to guarantee that these methods are validated. Standardization of these methods will assist in more accurate extrapolation of the similar effects in worlds and prevent such tragic events in future. Besides elaborate analysis of the comparative measurings of the binding affinities should be done for both human antigen and archpriest antigen, to command the unforeseen structural fluctuations of the proteins. If all these stairss were followed in instance of TGN1412, the awful event might hold been predicted and life of the voluntaries would non hold been on the hazard. A valuable lesson was learnt in the field of research that even a little faux pas in any portion of drug development might take to a large blooper and therefore careful hazard analysis and examination of each measure in the drug development in hereafter will greatly heighten the field of drug find, development and cut down the failure of possible drugs. Mentions: [ 1 ] N.Bhogal and R. Combes, Toxicology in Vitro Vol 21:1227-1232, 2007 [ 2 ] N.Bhogal et.al, ATLA 34,225-239, 2006 [ 3 ] E. Vitetta et.al, Perspective Immunology, Vol 313: 308-309, July 2006 [ 4 ] B. Schraven et.al, Immunity Vol 28:591-595, May 2008 [ 5 ] R. Stebbings et. Al, Current Opinion in Biotechnology, Vol 20: 673-677, 2009 [ 6 ] P.R. Ferguson, The SciTech Lawyer, Vol 5 ( 4 ) , 2009 [ 7 ] MJH Kenter and A F Cohen, Lancet, Vol 368:1387-1391, October 2006 [ 8 ] hypertext transfer protocol: //www.drugdevelopment-technology.com/projects/taranabant/ [ 9 ] Pacher et. al. , Arteriosclerosis, Thrombosis A ; Vascular Biology, Vol 29 ( 1 ) :7-9, Jan 2009 [ 10 ] C. Addy, Journal of Clinical Pharmacology, Vol 48: 418-427, 2008 [ 11 ] hypertext transfer protocol: //www.drugdevelopment-technology.com/projects/flurizan/
Thursday, March 12, 2020
The History of Kraft Foods
The History of Kraft Foods 1765: A Dorchester, Massachusetts, physician, Dr. James Baker, went into partnership with an Irish chocolate-maker, John Hannon and made Americas first chocolate mill.1780: The mill made the famous BAKERS chocolate.1880: The Empire Cheese Company of New York began producing PHILADELPHIA BRAND Cream Cheese for a New York distributor called Reynolds.1882: Isaac and Joseph Breakstone (Breakstone Bros) opened a small dairy store on New York Citys Lower East Side.1883: The now famous Oscar F. Mayer and his brothers Gottfried and Max started a meat market in Chicago.1889: Food salesman, William M. Wright, created a new baking powder called CALUMETÃ ® which he made at night and sold during the day.1892: Joel Cheek developed a coffee blend for the Maxwell House Hotel in Nashville, Tennessee, called MAXWELL HOUSE coffee.1946: MAXWELL HOUSE instant coffee was introduced to the American public after the armed forces used it in World War II.1895: In Battle Creek, Michigan, C.W. Post made the fi rst POSTUMÃ ®, a cereal beverage. Post created GRAPE-NUTSÃ ® cereal in 1897, and POST TOASTIESÃ ® corn flakes in 1908. 1897: Pearl Wait adapted an 1845 patent for a gelatin dessert. May Davis Wait named the new product JELL-O brand gelatin. In 1899, Orator Francis Woodward bought the trademark rights to JELL-OÃ ® for $450. Woodward launched the advertising campaign for Americas most favorite Dessert in 1902, thus ushering the era of psychological marketing.1903: J.L. Kraft started a wholesale cheese business in Chicago.1905: John Arbuckle created YUBAN coffee blend.1906: Oscar Mayer is one of the first meatpackers to obtain the Federal Meat Inspection stamp of approval.1907: Legend claims that when President Theodore Roosevelt was served a cup of MAXWELL HOUSE coffee and he proclaimed that it was GOOD TO THE LAST DROP.1914: J.L. Kraft Bros. Co. opened their first cheese factory in Stockton, Illinois, within a year they begin producing process cheese in tins. The U.S. government provided cheese in tins for the armed forces during World War I.1921: Louis Rich bought a truck and started his business i n Rock Island, Illinois. 1927: Edwin Perkins created a powdered fruit drink called KOOL-ADE, later called KOOL-AID. Perkins created KOOL-AID from his first product the popular soft drink syrup called Fruit Smack. The same year the Postum Company marketed SANKA decaffeinated coffee (first sold in the U.S. in 1923).1928: Kraft introduced VELVEETA process cheese.1933: Kraft introduced MIRACLE WHIP salad dressing at Chicagos Century of ProgressWorlds Fair.1936: Little Oscar and the WIENERMOBILE started the advertising campaign for Oscar Mayer Co.1937: KRAFT Macaroni and Cheese Dinner were introduced with the advertising slogan of Make a meal for 4 in 9 minutes.1949: MINUTE Rice was nationally distributed.1950: KRAFT Deluxe process cheese slices, the first commercially packaged sliced process cheese was introduced.1952: CHEEZ WHIZ pasteurized process cheese spread was introduced.1954: Kraft introduced CRACKER BARREL brand natural cheese.1957: The General Foods Corporation introduced TANG, breakfast beverage crys tals. 1963: The now famous wiener jingle first appeared in Oscar Mayer commercials.I965: The company introduced SHAKE N BAKE coating mix in two versions, chicken and fish.1966: COOL WHIP nondairy whipped topping was introduced.1972: STOVE TOP stuffing mix was introduced.1973: GENERAL FOODS INTERNATIONAL COFFEES flavored coffees were introduced.1981: General Foods Corp. bought Oscar Mayer Co.1983: Kraft introduced LIGHT N LIVELY low-fat yogurt, the first US yogurt in a six-pack.1985: Philip Morris Companies Inc. buys general Foods Corporation.1986: Kraft purchased Tombstone Pizza Corporation of Medford, Wisconsin (est.1962).1988: Philip Morris Companies Inc bought Kraft, Inc. Oscar Mayer introduced LUNCHABLES.1989: Philip Morris Companies combined Kraft, Inc. and General Foods Corporation to form Kraft General Foods, the largest food company in the U.S. DI GIORNO brand refrigerated pasta and sauces were introduced.1993: Kraft General Foods acquired NABISCO ready-to-eat cold cereals from RJ R Nabisco. 1995: Kraft General Foods was renamed Kraft Foods, Inc. DI GIORNO RISING CRUST pizza was introduced.1996: BREAKSTONES snack-size cottage cheese, the first four pack of 4-ounce cups.1997: POST-Cranberry Almond Crunch and POST Honey Nut Shredded Wheat cereal was introduced. Sparkling White Grape flavored JELL-O gelatin was introduced in celebration of the brands 100th anniversary.1998: STOVE TOP OVEN CLASSICS were introduced. The same year KRAFT introduced EASY MAC macaroni and cheese dinner, a microwavable, single-serve product.
Tuesday, February 25, 2020
Competing SBU Essay Example | Topics and Well Written Essays - 750 words
Competing SBU - Essay Example This paper will focus on three of its business units namely Enterprise Servers, Storage and Networking (ESSN), Personal Systems Group (PSG) and HP Software, HP Financial Services (HPFS). The ESSN business unit concentrates on the provision of server, storage as well as networking products within a range of categories. The Converged Infrastructure portfolio of the Company in terms of servers, storage coupled with networking together with Cloud Service Automation software suite by the HP Software business unit form the CloudSystem of HP. Such an integrated solution comes in handy in enabling clients within the enterprise and service department in the delivery of infrastructure platform in technology. This means that the Industry Standard Servers develop the basic entry-levels as well as ProLiant servers (mid-range) that run Windows, Novell and Linux operating systems and Advanced Micro Devices (AMD) and Intel Corporation (Intel) processors (Pham-Gia, 2009). The overall business spans o f this scope of the product line include the pedestal-tower servers as well as the density-optimized rack servers within the BladeSystem family of HP in terms of the server blades. The PSG business unit provides calculators, commercial personal computers, workstations, consumer PCs and related accessories, services and software for the consumer and commercial markets. The unit collects commercial workstations, commercial notebooks and desktops into consumer notebooks and commercial clients and consumer desktops for their clients. The main products of these elements include Commercial PCs such as the HP EliteBook and the HP ProBook lines of notebooks. Also, there are Compaq Elite, Compaq Pro, HP Elite and HP Pro lines of the business desktops coupled with the HP Mini-Note PCs, retail POS systems, Omni and TouchSmart PCs, HP Slate Tablet and HP Thin Clients PCs (House & Price, 2009). The HPFS business unit supports HP's service and product solutions on a global scale towards providing a comprehensive scope of financial management services in its life cycle. The HPFS is an enabler of worldwide customers into the acquisition of IT solutions such as hardware, software and services. This means that the Company will offer financing, leasing, utility programs coupled with asset recovery services in terms of financial asset management services to enterprise and global customers. HPFS also avails a wide array of specialized financial services to SMBs and governmental and educational entities. One of the strengths of Enterprise Servers, Storage and Networking (ESSN) is that the economy of the world keeps growing steadily every year. For this reason, such growing economies come in handy in accelerating corporate expenditure where HP is positioned to continue benefiting. The business unit has in turn increased the levels of investments in the global markets while still expanding the product as well as service offerings with special regard to its enterprise services and bus iness divisions. The divisions provide most products on a profitable scale for cloud computing services as well as enterprise solutions. However, a major weakness of Personal Systems Group (PSG) is that strategic expansion into diverse markets could result in stronger competition against the products of the business in the future (Pham-Gia, 2009). This is based on the fact
Thursday, January 30, 2020
Using Affirmative Action to Promote Womens Essay Example for Free
Using Affirmative Action to Promote Womens Essay The empowerment of persons who are vulnerable and excluded, promotion of social justice and equity are the main concerns of social policies, and this should transcend all aspects of society, including participation in governance and decision making. Inspite of the pivotal role women in Ghana play within the family, they are invisibly represented in governance and decision making sector of the economy. This is because there is no concrete policy measures in place to ensure that the structural inequality between men and women are taken into account in promoting participation in policy decision. Efforts are being made at various levels to address the marginalization of women in Ghanaââ¬â¢s politics and other spheres of life, but this still remains an area of concern. In a country where women constitute about 51 percent, their involvement in development issues and political leadership should be of grave concern, and given due consideration. Affirmative action Policy is therefore viewed as the appropriate instrument to enhance womenââ¬â¢s participation in governance and decision making in Ghana. This paper will therefore review womenââ¬â¢s participation/empowerment in Ghana; outline various commitments seeking to enhance womenââ¬â¢s participation in Ghana; the Affirmative Action Policy and finally look at expected outcomes of the Affirmative Action Policy and how it will enhance womenââ¬â¢s participation in Ghana. WOMENââ¬â¢S PARTICIPATION IN GHANA Although there is no law in Ghana that prevents women from participating in politics or in areas of Ghanaââ¬â¢s economic or social life, women are generally under-represented in politics and in public life. There seems to be no long term strategic framework put in place to address this failure. This has been attributed to a lack of political will and a deficient commitment to gender equality among political parties. Gender advocates have asked that government and its agencies, political parties and relevant public and private institutions should take actions that ensure and assure their active commitment to improving the current situation of womenââ¬â¢s low representation in politics and public appointive positions at all levels.
Wednesday, January 22, 2020
harry potter :: essays research papers
Book Report 1.à à à à à My book report is on Harry Potter and the Chamber of Secrets by J.K. Rowling.2. The setting of this book takes place at Hogwarts, a magical school for wizards that Harry Potter attended the previous year. The story doesnââ¬â¢t exactly have a date in which the story takes place but itââ¬â¢s in modern times.3. The plot of the story is about Harry and his adventure in trying to find out the mystery of the chamber of secrets hidden somewhere in Hogwarts. 4. A.Harry Potter is the main character of the story. Heââ¬â¢s a twelve year old boy with messy hair and glasses who became famous within the wizard community. He often finds himself in dangerous adventures but always lives to tell about it. B. Ron is Harryââ¬â¢s best friend at Hogwarts. Heââ¬â¢s tall with red hair and is from a respected but poor family. Ron uses experience and a process of trial and error to solve most mysteries. 5. A. One major conflict that had happen in the story was how Harry thought he couldnââ¬â¢t go to Hogwarts because his aunt and uncle wouldnââ¬â¢t let him out of his room. This conflict was solved however because Harryââ¬â¢s friend Ron came in a flying car and picked him up out of his window. B. Another conflict that happened in the story was how Ronââ¬â¢s sister started acting strangely weird and kept being put under these trances. She somehow disappears and is missing. This conflict was resolved by Harry finding the chamber of secrets and looked for her. He eventually found her. C. One more conflict that happened was who was causing all the mischief at Hogwarts. This conflict was resolved when Harry found the chamber of secrets and fought Tom Riddle. 6. The story ends by Harry going into the chamber of secrets and finding Tom Riddle there with Ginnyââ¬â¢s still body. Tom summons a giant snake. Harry fights the snake and defeats it. Harry then sticks one of the snakesââ¬â¢ fangs into the diary and defeats Tom.
Monday, January 13, 2020
JpMorgan Case Essay
We trust banks to hold our money and to help make use get more in investment and other ways. One of the most trusted banks is J.P. Morgan Chase they are easily one of the most well-known banks that exist. J.P. Morgan Chase on May 10, 2012 disclosed that they had lost more than $2 billion by trading financial derivatives. The administrative agencies like the Securities and Exchange Commission (SEC) or the Commodities Futures Trading Commission (CFTC) take action in order to be effective in preventing high-risk gambles in securities and banking, a foundation of the economy. We have to understand the elements of a valid contract, and discuss how consumers and banks each have a duty of good faith and fair dealing in the banking relationship. Having to compare and contrast the differences between intentional and negligent tort actions. Iââ¬â¢ll discuss the tort action of ââ¬Å"Interference with Contractual Relations and Participating in a Breach of Fiduciary dutyâ⬠and, if the bank Iââ¬â¢ve chosen were to behave as JP Morgan did, would I be able to prevail in such a tort action. Lastly letââ¬â¢s discuss how banks have protected the software that allows for online transaction to occur through automation.7 The U.S. Securities and Exchange Commission (SEC) is a federal agency. It holds primary responsibility for enforcing the federal securities laws and regulating the securities industry, the nationââ¬â¢s stock and options exchanges, and other electronic securities markets in the United States. The SEC is divided into four divisions; The Division of Corporation Finance; the Division of Trading and Markets; the Division of Investment Management; and The Division of Enforcement. All the branches within the SEC carry similarà goals in terms of protecting individuals and ensuring financial fairness, each has their own specialty for instance, the Division of Corporate Finance is tasked with the assurance that all imperative disclosure of which represent a corporation are easily accessible by the general public. In addition, the Division of Trading and Markets ensure fairness, order and efficiency in market activities. Much like the design of the SEC, the Commodity Futures Trading Commis sion (CFTC) is also inherently designed to ensure the public, its consumers, and investors are protected from coercion, manipulation, fraud, and/or any other forms of dishonest dealings between manufacturer and consumers/investors. The CFTC is noted to be an independent federal agency established by the Commodity Futures Trading Commission Act of 1974. Again, similar to the design of the SEC, the CFTC is comprised of five different committees, each of which are responsible for a different area of trade and marketing; for example, agriculture, global markets, energy and environmental markets and technology all of which are equally as responsible as the next for ensuring full cooperation and adherence to laws set forth by the SEC. Though banking is the most common method in which most people handle and maintain their finances, there are also equally as many that take their money to invest in stocks, bonds, and the like which do not carry a sound guarantee that they will make a profit or even keep their initial investment monies. Consequently, past dealings with investor types result in unfair and fraudulent losses and even erroneous gains such as the ones reported by JP Morgan Chase, the purpose of the SEC and CFTC alike become abundantly clear. With the utilization of these two particular securities, investors, consumers, and even marketers are able to rest easier knowing that there are serious legal, unfair and blatantly dishonest dealings within the marketplace. In an effort to maintain honest correspondence and dealings with the capital market, both of these require that all earnings and losses should be reported; at which point, there can be a recognition and determination of any imbalanced and deceitful dealings having taken place. The following are the essential elements of a valid contract. Offer and Acceptance. In order to create a valid contract, there must be a ââ¬Ëlawful offerââ¬â¢ by one party and lawful acceptance of the same by the other partyà Intention to Create Legal Relationship. In case, there is no such intention on the part of parties, there is no contract. Agreements of social or domestic nature do not contemplate legal relations. Lawful Consideration has been defined in various ways. The parties to an agreement must be competent the contract. If either of the parties does not have the capacity to contract, the contract is not valid. Free Consentââ¬â¢ means the parties must have agreed upon the same thing in the same sense. In the banking context, this means among other things that a bank could call a loan, refuse to fund, refuse to roll over a loan, set off accounts, etc., no matter how drastic the consequences might be to the borrower. As long as the banks accept them expressly wit hin the granted rights under the controlling loan documents. That may no longer be the case. With the advent of mobile banking, discuss how banks have protected the software that allows for online transaction to occur through automation. The first area, financial accounting, is used mainly for ascertaining the results of any such business on a periodic basis. This should as a result; help the company determine the future course of action, in the long term. From an economic perspective, financial accounting treats money as a factor of production. Management and cost accounting are apparatus used to help management make decisions on a day to day basis. Management and cost accounting arenââ¬â¢t useful simply for their own sake. These two functions help management conduct themselves along with other vital factors involved in the running of a business. Other key factors could be supply, demand, competitors, availability of raw materials, logistics etc. The second area is cost accounting, its primary purpose is to attain the value of direct and indirect costs involved in production. The value acquired, management can make an informed decision on improvement in production performance. From an economic perspective, cost accounting is the measurement of economic performance. This information gives management a clearer indication of the performance of the product resources in the business. Costing also helps the sales manage in setting the correct price. But, because costing is solely a measurement of economic performance, it canââ¬â¢t be considered as an accurate basis for setting prices. Selling prices is more of an economic decision it would not be wrong to mention that pricing is basically determined by marketà factors. Prices are influenced mainly on demand, supply and competition, less on costs. High demand plus lack of competition would result in the business charging higher prices for its product, well above the costs. The third area is management accounting, which is related closely to cost accounting. It has evolved from cost accounting; management accounting plays a much broader role in management decisions. It measures the performance, economically, of the whole business, the economic environment that the business operates in. This area of accounting, seeks to combine both financial and cost information into a much broader function. Compare and contrast the differences between intentional and negligent tort actions. Intentional torts and negligence towards both give rise to civil actions. However, there are some important differences to understand about negligence versus intentional torts. Negligence torts do not require intent. To determine if someone should be found liable for a negligence tort, a reasonable person standard is used. If the defendantââ¬â¢s behavior is found to be less careful than behavior a reasonable person would exhibit, that defendant can be found liable for damages. Intentional torts require intent. The person who committed to tort must have intended to cause harm. The harm, however, did not need to be the specific type of harm that was caused to you. The other major difference between intentional and negligence torts, aside from the standard of proof, is that in many cases, a person who is found liable for an intentional tort can be required to pay punitive damages in addition to actua l damages. Discuss the tort action of ââ¬Å"Interference with Contractual Relations and Participating in a Breach of Fiduciary dutyâ⬠and, if the bank youââ¬â¢ve chosen were to behave as JP Morgan did, would you be able to prevail in such a tort action. The tort of interference with contractual relations and participating protects the right to enjoy the benefits of legally binding agreements. I have chosen a bank like JP Morgan and they did what he I would not took it very well. I invested money and knowing that JP losses that money I would wind up probably suing them. But providing a remedy when the defendant intentionally induces another person to breach a contract with the plaintiff. The defendant must know of the existence of the contract between the plaintiff and the other person, or there must be a sufficient fact that a reasonable person would be led to believe that suchà contract existed. Interference with the contractual relations requires an unacceptable purpose. If good grounds are set and exist for the interference then the defendant is not liable. But as for J.P. Morgan there were no good rounds so the defendant is liable. So if I were to go to court over this I would not win and neither would J.P we would just be both out of the loss money that was invested. In conclusion when you invest money in a bank Think to you self is it a good idea or is it not a good idea. We all make investments just need to make sure it in the right bank that you can trust. J.P Morgan had a down fall and loss a ton of money but in the end they had to deal with the fines and the investors. When in drought donââ¬â¢t invest your money unless you really have to. References: Bagley / Savage 2013 Custom Edition http://money.cnn.com/2012/05/10/news/companies/jp-morgan-losses/index.htm http://www.thedailybeast.com/
Sunday, January 5, 2020
How Is The Corporate Governance Affected By Globalization Finance Essay - Free Essay Example
Sample details Pages: 24 Words: 7098 Downloads: 3 Date added: 2017/06/26 Category Finance Essay Type Narrative essay Did you like this example? Corporate governance appears to be a particularly important topic nowadays, when ownership rights and control over assets in corporations are separated, and the top management of corporations might not act in the interests of stakeholders. There are numerous corporations all over the world, and their effect on the world economy is quite substantial. Corporations as one of the most complicated structures of a firm appear to be also the most powerful regarding its influence on economic development and political decision-making process. Donââ¬â¢t waste time! Our writers will create an original "How Is The Corporate Governance Affected By Globalization Finance Essay" essay for you Create order Considering the importance of corporations to the national economies and shareholders concern over level of protection of their investments, it is particularly relevant to be well aware of the governance systems inside corporations, their policy of shareholders treatment and their level of subordination to the state. These paper aims to explore, how entering the international market affects the corporate governance of corporations. Our research question is How is the corporate governance affected by globalization? The research that we conducted will be useful for exploration of globalization effect on the world economies, and it is as well relevant for those, who have interest in topics related to corporate governance and its dependence on exogenous conditions. To answer our research question we will rely on the following institutional economics approaches: agency theory, transaction costs theory, business ethics theory. We opted these four institutional theories, as they are the most relevant to explain the current changes in corporate governance of German companies as they enter Ukrainian market. In our research, we focus on the effect of Ukrainian market conditions on the governance system of foreign corporations that enter the national market, in our case we analyze German corporations. Both of these countries are in the continental Europe, thus Germany adopted the European type of capitalism. However, it is rather hard to determine what kind of capitalism Ukraine adopted after the break- down of the Soviet Union. We will use real examples of corporations operating in these countries to evaluate the changes in the corporate governance brought by the differences of the background, and to show the consequences the globalization in these c ases led to. The paper contains six main chapters. Chapter 2 provides reasoning for the choice of the countries that are analyzed in the paper. Chapter 3 is a review of four institutional economics theories that we use to analyze the corporate governance in Ukraine and Germany in further chapters. In chapters 4 and 5 we describe and explain main changes in corporations and corporate governance in Ukraine and Germany correspondingly. In these chapters we also focus on the particularities of corporations operating in these countries from the perspective of state of economy, level of political stability, state intervention in private sector and social factors. Chapter 6 is a study case of few German corporations (METRO AG, Henkel etc.) operating in Ukrainian economy. This chapter is an empirical proof of the differences in corporate governance, corporate legislations and their effects in two chosen countries with our comments and advises on possible changes, relying on material provided in previous chapters. 2. Germany and Ukraine. Reasoning for the choice of the countries. Germany and Ukraine are for the time period one of the most unique economies in the world. Both based on heavy industry those two countries are one of the wealthiest countries in Europe. The time during the Germanys division and the occupation of Ukraine is a black-spot in economic history, regarding both those countries. However, in late 1980s and early 1990s, after the break of Soviet Union, many countries regained their independence thus allowing them to choose their own economic path. Germany, was separated in year 1961, when the soviets built a wall, which divided Berlin into Eastern and Western parts, thus part of Germany as well, into two economic blocks; one of which was Western or capitalistic, and the other one Eastern or communistic. On the other hand, Ukraine shared rather similar destiny in historical perspective. In 1922 Ukraine became a part of USSR (The Union of Soviet Socialist Republics), thus determining their fate for socialistic regime, under control of Soviet Russia. Both, Ukraine and Eastern Germany, managed to escape the Soviet control in late 1980s (1989 for Germany and 1990- Ukraine), thus allowing them to be independent and choose their own paths and make their own decisions. The term corporate governance is used in two distinct ways. In Anglo-Saxon countries like the US and UK good corporate governance involves firms pursuing the interests of shareholders. In other countries like Japan, Germany and France it involves pursuing the interests of all stakeholders including employees and customers as well as shareholders (Allen, F., Gale, D. (2002). A comparative theory of corporate governance. Social Science Research Network, Http://papers.Ssrn.com/sol3/papers.Cfm). The economic paths that Ukraine and Eastern Germany chose were rather different. The main differences were the corporate governance control. The united Germany adopted the continental European corporate governance model, whereas for Ukraine, a rather young and inexperienced country, they chose to adopt Anglo- Saxon corporate governance. The main differences about those two corporate governance systems were noticed by WladimirAndreff :In Continental Europe corporate governance, there is no domestic external market for executive talent and, thus, when a German (or any other continental European) CEO is appointed there is no negotiation (about salary, stock options, performance bonus, retirement provision and the like). The second difference is in wage negotiations between the enterprise union and managers. Anglo- Saxon firms behave in both cases as properly capitalist; continental Europe firms, by contrast, are more seen like communities. The latter employee- favoring firm opposes the former shareholder-favoring firm(Andreff, W. (2002), Journal of international business studies, Vol. 33, No 1, pp.195- 197, accessed on 23/10/2010). The industries both countries chose were similar. Germany and Ukraine are both famous for their heavy industries, such as machinery industry, and the IT business. However, the main exporting areas of the countries differ greatly. Ukraine still bases most of its economy on Russia. Not only it exports most of its goods there, but also imports the most of countrys energy (gas, oil, electricity) from Russia. Whereas, Germany, is internationally well known for its car industry and home technic. Therefore, the German corporate governance is in relationships with many other different countries, which have different institutional systems, thus making German governance system to adopt in its own way. On the other hand, Ukraine, basing its main relationship with Russia, had to adopt other meanings of doing transactions. Corruption and government incompetence made the cooperation between western countries and Ukraine rather difficult. According to MSI (Management Systems International):Ukraine can be categorized as a closed insider economy ÃÆ'à ¢Ã ¢Ã¢â ¬Ã à ¢Ã¢â¬Å¡Ã ¬ a country strongly influenced by elite cartels (MSI, (February 10, 2006), Corruption Assessment: Ukraine). In conclusion, both countries have their own similarities and differences. Ukraine and Germany share rather similar historic background until the 80-90s of XX century, however, after both countries escaped the influence of USSR, affected by globalization, they took different paths following different choices, as an example governance structure. Neither of their choices were wrong. Out of these reasons this paper will be analyzing the corporate governance particularly in these countries. Institutional economics theories used in the analysis of the corporate governance (Agency, Transaction, Business Ethics). There are many different approaches, which are possible analyzing countries. The theories this paper will be focusing on are: Transaction cost, Agency and business ethics. Those theories were chosen due to several reasons. Firstly, transaction cost theory would be particularly interesting to apply to German corporate governance, as German corporations have transactions with different firms in different countries, as for Ukraine corporations, it mainly deals with Russia and other post Soviet countries, such as: Belorussia, Lithuania, Latvia, Kazakhstan. Secondly, agency theory would show how different agents and principles manage the transactions. In Germanys perspective, they have many branches of their companies around the world, thus making it rather hard to rule. More over, the difference in chosen corporate governance in Ukraine and Germany makes it interesting to analyze how are firms agents treated and rewarded in both these countries Lastly, the business ethics part will mostly concern Ukraine, as the level of corruption in the country is rather high, thus making it rather difficult for international corporations to take part in Ukraines economic development. As for Germany, it will interesting to see how do the branches of corporations situated in different countries, where corruption level is higher/high, avoid the corrupt structures. 3.1. Transaction cost theory The transaction cost is a cost incurred in making an economic exchange/ or participating in a market (Wikipedia.org, accessed on 23/10/2010). There are many different ways to calculate transaction costs. Also, the transaction cost mostly wants firms to cooperate, as lower the transaction costs lead to higher profit, thus making long-term contracts applicable and wanted. As Hanna Kuittinen argues, The inter-Ãâà ¬Ãâà rm cooperation is more efÃâà ¬Ãâà cient than the use of open markets or hierarchies when it minimizes the difference between the Ãâà ¬Ãâà rms transaction and management costs (i.e. the governance costs) at the same time as the value of its dynamic governance beneÃâà ¬Ãâà ts is maximized(Kuittinen, H., Jantunen, A., Kylahenko, K., Sandstrom, J. (13 September 2008) Cooperation governance mode: an extended transaction cost approach , pp. 307). However, making contracts with other party, needs trust, therefore, the reputation and uncertainty part starts to play an important role in reducing the transaction costs. Especially when long term relationships are being on stake, the reputation determines, whether the contract will be made or not. Moreover, even if the contract is made, uncertainty still might determine the relationships between the firm, as Hanna Kuittinen reasons: Uncertainty about future outcomes makes it difÃâà ¬Ãâà cult to specify contracts ex ante, and behavioural uncertainty complicates the coordination during the transaction and evaluation of the performance ex post (Kuittinen, H., Jantunen, A., Kylahenko, K., Sandstrom, J. (13 September 2008) Cooperation governance mode: an extended transaction cost approach , pp. 310) 3.2. Agency theory Agency theory treats the difficulties that arise under conditions of incomplete and asymmetric information (Wikipedia.org, accessed on 23/10/2010). The most important part is the asymmetric and incomplete information in these days economy. Principle hiring a new agent for its company is never certain about the validity of his documents or experience. So how should principles determine the agency costs? If they would over evaluate the agent it might come out that the new employee does not sufficiently do his job as expected, however if the agent is under paid, he might start shirking and not try do his best. As Claudia Keser and Mark Willinger argue low incentives can affect participants in a contradictory way because of a possible conÃâà ¬Ã ¢Ã¢â ¬Ã
¡ict between intrinsic motivation and Ãâà ¬Ãâà nancial reward. Furthermore, it can be concluded from a vast survey of experiments that in some cases incentives improve performance, and in other cases they have no effect, o r even worse, hurt performance. (Keser, C., Willinger, M., (2 October 2006), Theories of behavior in principal-agent relationships with hidden action, pp. 1527). 3.3. Business Ethics Business ethics I can either be institutional or personal in scope. Institutional business ethics deals with broad, somewhat impersonal and abstract issues of the ethics of corporations as institutions. An example of this is corporate social responsibility(Pattan, E., J. (1984), The Business of Ethics and the Ethics of Business, pp. 1). As stated by John E. Pattan, personal or institutional, in this paper we will try to concentrate on the institutional point of view. We make ethical judgments every time we feel that our interests or opinions are promoted or attacked, our rights respected or violated, or ourselves catered to or threatened (Pattan, E., J. (1984), The Business of Ethics and the Ethics of Business, pp. 3) The main purpose of business if not a secret, every businessman wants to maximize his profits. But what moral costs does it involve? In some cases it might involve corruption, stealing sometimes even taking lives of others. Therefore, it will be studied, how do institut ions deal with each other and how are ethics implied to their decisions. Corporate governance Ukraine Introduction to the corporate governance in Ukraine. In the given paper we regarded the period of the economic development of Ukraine, starting from 1990 year. That time was remarkable for the fall of the Berlin Wall and the collapse of the central planning and command structures that had been in forces for 70 years. The country started implementation of reform programs aimed at market economy and globalization (Holmstrom, Smith, 2000). The leading enterprises and companies in Ukraine realized the importance of effective corporate governance. The reason is that it is the key factor determining the microeconomic efficiency of the enterprise sector and the quality of investment climate of the country. According to A. Kostyuk the German model is getting spread in the Ukraine from year to year (Board Practices; An International Review2003). The main evidences are small quantity of independent directors on the board, rare meetings of the board, not big number of committees on the board, the management board affects the supervisory board. There are nearly 35 thousand joint stock companies in Ukraine that is comparatively more than in many developed countries. Every year the state commission on securities and stock exchanges states about over 12 thousand of cases of breaking the principles of corporate governance in the country. In this case, it is significantly to regard the role of ownership structure in corporate governance. It is important to know why owners purchase shares and what corporate mechanisms they use. (A Kostyuk 2002). The cause of closing of board practices in Ukraine is the rise in concentration of ownership, which results in rise in corporate control, violation of minority shareholders rights, rise in number of disputes, conflicts of interests and decrease in transparency of the Ukrainian joint stock companies. Ãâà Ãâà Ãâà Database provides annual financial statements in total for 14356 companies, in particular 2215Ãâà corporations in 1998, 8325 corporations in 2000 (out of 11850 registered), 7735 corporations in 2001Ãâà (out of 12039 registered) and 10213 corporations in 2002 (out of 12010 registered). For the empirical testing we use the dataset of 10313 observations on manufacturing open joint-Ãâà stock companies in total, in particular 4337 firms in 2000, 3385 in 2001 and 2591 in 2002. Thus theÃâà sample covers around 37%, 28% and 21% of all open joint-stock companies in Ukraine in 2000, 2001Ãâà and 2002 respectively. The data is collected from publicly available information, in particular, fromÃâà annual financial statements of Ukrainian joint-stock companies (Source: PFTS First Trading StockÃâà System, Istock database:Ãâà www.istock.com.ua), (Corporate governance in Ukraine Vitaliy Zeka ). Nowadays corporations in Ukraine are divided into joint stock companies founded pursuant to Law of Ukraine On business association: Open Joint Stock company Close Joint Stock Company Ukrainian Joint Stock Company Ukrainian Private Joint Stock CompanyÃâà The biggest companies in Ukraine are: Company Profit Sector Naftogaz Ukraine Ukraine 6.126.451(Energy/Commodities), Mariupolskij Metkombinat Ukraine 2.382.034(Industry), Azowstal Ukraine 2.059.265(Industry) , Linos Ukraine 1.923.149(Energy / Commodities), Mittal Steel Kriwoj Rog Ukraine 1.836.833 (Industry), Industrialnyj Sojuz Donbasa Ukraine 1.750.239(Industry), Ukrtatnafta Ukraine 1.460.350(Energy/ Commodities), Zaporozstal Ukraine 1.325.41(Industry). Directors can be nominated by the supervisory and the management boards independently. At least 25 % of Companies with where controlling block of shares (50 percent +1 share) belongs to one owner, have boards with 5-6 members. They represent interests of the controlling shareholder. (A Kostyuk 2002) In accordance with Article 118 of the Commercial Code of Ukraine, basic shareholder rights are established by law. The width of shareholders rights in Ukrainian firms may vary and depends on whether the joint stock company has free circulation of shares (an open type) or its shares are distributed among the founders and cannot be traded on stock exchange( a close type) . Companies controlled by the foreign institutional investors or Ukrainian investment companies have 7 or 9 members on the board (see the Commercial code of Ukraine). Supervisory board members at Ukrainian joint stock companies meet every quarter. Boards at the companies, where the ownership is strongly concentrated, hold meetings less frequently than at those companies, where the corporate ownership is spread. This is because of controllers have a chance to have both the supervisory and the management boards under their control. The procedure of nominating new directors in Ukraine is plain and chaotic. Shareholder may nominate committees by themselves. In order to do this, they must possess enough stake in enterprise. Each shareholder who possesses shares of the enterprise above 2 % of shareholders equity can offer his own candidate on the supervisory board. As we see from the chart, 44% of elected directors were nominated by shareholders. 31 % of elected directors were nominated by the management board. Only 25% of directors were nominated by the supervisory board. (A. Kostyuk 2002). In other words, shareholders wish to be controllers through electing directors and executive who would represent their interests.Ãâà Groups of the director nominators and their efficiency in nomination Supervisory boards at Ukrainian joint stock companies are not independent. Some of them possessÃâà largeÃâà share of equity of the companies. The researches show that only about 8 % of board directors are independent.Ãâà There is evidence that 42 % of Ukrainian joint stock companies have no independent directors on supervisory board. About 31 %of researched companies in Ukraine have not more than 1 independent director .Companies have policy committee, which are under control of foreign institutional investors.Ãâà Directors can be nominated by the supervisory and the management boards indecently. The companies with dispersed ownership structure have a practice of nominating directors by governing corporate bodies. All candidates must be shareholders . Ãâà Definition of Corporate Governance. The term corporate governance can be interpreted as the system of legal and economic institutions that create formal and informal regulatory system, which determines behavior of enterprise. (Piotr Kozarevswski 2009). Mechanism of concentration of corporate ownership structure in Ukrain during 1998-2001 is illustrated by next figure. (Kostyuk, 2007) The researches ofÃâà Saul Estrin, Adam Rosevear, AlexÃâà Krakovsky, Alex PivovarskyÃâà helped usÃâà greatly Ãâà to understanding theÃâà issue of corporate governance mechanisms in Ukraine. All these expertsÃâà considered that many corporate governance mechanisms, such as the boardÃâà of directors, financial reporting etc, hardly work in Ukraine.Ãâà According to Alexander N. Kostyuk (Corporate Governance in aÃâà transition economy 2007) One of the well-known reasons is the absenceÃâà of an Act of Joint Stock Companies. The draft of this Act had beenÃâà presented in 2001. However, the Act has not been approved by theÃâà Ukrainian parliament, where a strong political lobby protects theÃâà rights of large owners, named oligarchs. Therefore, joint stock companies in UkraineÃâà have to work with reference to The Act of Enterprises, which does notÃâà explain the nature of many corporate governance mechanisms, s uch as boardÃâà committees,Ãâà executive directors,Ãâà executiveÃâà monitoring, etc. As the result, corporate governance in Ukraine allows violation of minority shareholders rights, weak transparency and inadequateÃâà corporate social responsibility. Under such circumstances, one of theÃâà ways out is through developing a set of internal statements to makeÃâà all these corporate governance mechanisms work. Evidences of corporate governance in Ukraine. There is evidence on corporate governance, which we observed while studied the statistical data on corporate governance in the country. Our survey reveals that performance at the enterprise level has also not been improving, average output, employment, and productivity in Ukrainian firms have fallen every year since 1990 and profitability has been uniformly low, if not negative. Moreover restructuring has been very modest, although rather more differentiated across enterprises. For example there has been little increased trade with the West on average only 2%of enterprise sales in 1996 went to OECD countries, up from 0.5 % in 1999. Investment has also been low, so capital stock is largely obsolete. (Saul Estrin Adam Rosevesr, 1999) This is another example we may apply for. In the average firm in Ukraine , the number of managers holding shares is around 15 , while the number of employees is 599 and former employees is 302. Holdings by Ukrainian citizens and companies are also highly dispersed at 1065 and 616 shareholders on average respectively. However, the typical number of shareholders, which are banks, foreign individuals and foreign firms, is one and investment fund is two. The basic conditions for fundamental structure change in company corporate governance in Ukraine are still weak and need for radical policy changes and capital market development to make company corporative governance more effective (Saul Estrin Adam Rosevesr, 1999). After we studied the supervisory board practices in Ukraine, we may conclude the following: they are small in size, lack of legal employee participation in the corporate governance, rare meeting of board, small number of committees on board, management board influences, supervisory board, small number of independent directors. Analysis of corporate governance in Ukraine from the approach of agency theory. The Principal- Agent relations exist when one person called the agent acts on behalf of another, called principal. The welfare of the principal is affected by the choice of the agent.Ãâà In companies it is the shareholder who acts as the principal and company directors act as the agent. Ãâà This interaction works well when the agent is a professional at making the necessary decisions, but contrary doesnt work well when the interests of the principal and agent differ. Ãâà There is possibility of opportunistic behavior on the part of the agent that works against the welfare of the principal (Baza Oba, 2004 ). Most of agents actions in the companies are unknown to the principal or expensive to obtain.Ãâà Ãâà As applied to corporate governance in companies in Ukraine the second practice is common. The absence of accounting and audit norms in Ukraine as we mentioned above, leadsÃâà to corruption and bureaucracy. All these prevent the Ukrainian companies from bringing simultaneous capital, access to Western , technology, markets and managerial expertise ( Estrin Rosevear, 2003 ). Analysis of corporate governance in Ukraine from the approach of transaction costs theory. In order to be able to transact at all and to transact safely, actors have to incur costs to find out how and where transaction opportunities occur, and about the possibilities the possible risks and uncertainties involved. These expenses are called transaction costs. Market transactions consist of several aspects: 1. Search and information costs (who offers the product? Is the seller the owner? What are the conditions?) 2. Costs to draft, to negotiate and to conclude the contract. 3. Monitoring costs and enforcement costs. These are the costs that are incurred to make sure that the other party commits to an agreement, whether this is of a private nature or a public nature (John Groenewegen, 2010). According to Vladimir Andreff ( 2006), along with contract corporations (enterprises, established on the basis of the contract) there are a large number of corporations formed to address public authorities public corporations typically, in business practices of Ukraine. These corporations are successors of the reorganized ministries, state committees, departments and state enterprises to unite industry, or other principles. (Inna Pidluska, 1998) Analysis of corporate governance in Ukraine from the approach of business ethics theory. Its of common knowledgeÃâà that no universal model ofÃâà corporate governance exists. However,Ãâà there are generally accepted standards of good corporate governance. They may be applied in the frames of legal, economic and political aspects. InternationalÃâà principles of corporate governance appeared as a result of increased public interest in corporate governance, which was generated by the globalization of financial markets and the capitalization of capital flows.Ãâà Ukraine is notoriously famous for engagingÃâà inÃâà corruption openly and freely. Ukraines President Leonid Kuchma has identified the main obstacle to business development as bureaucratic abuse of power, bribery and extortion. He also admitted that the government has failed to create conditions for conducting business honestly. (Inna Pidluska, 1998) After the Orange Revolution the government of Ukraine has seen itÃâà fit to sell business off to rich elite. It leads to the rise of the business oligarchs who have taken over the exercising state power into their own hands. So calledÃâà shadow economy was flourishing (Egger and Winner (2005). In modern Ukraine giving a bribe is a regular everyday routine. To give a bribe to an inspector who checks the required norms in the company, or win a tender using special privileges, became a norm in Ukraine. Average Ukrainian manager spends two days per week on inspection issues.Ãâà (Inna Pidluska, 1998) The facts of double accounting and money laundering is a widely spread practice in a shadow economy of the country. The size of Ukraines informal sector, or shadow economy, reflects the high degree of corruption. It is currently estimated that seven out of ten enterprises work in the shadow economy. These companies have no protection from corruption and are open targets for bribery and other forms of graft. (Inna Pidluska, 1998) Nowadays, UkraineÃâà is making a concerted effort to improve corporate governance at the national level. This goal can be achieved through the implementation of national Code of corporate governance. Problems of corporate governance in Ukraine must be addressed through introduction of standards of ethics and a code of practice for corporate governance. Business ethics is mainly aimed at promoting good reputation of the company at the market. TheÃâà most important principles areÃâà responsibility andÃâà freedom. Employees and partners are individuals. They should beÃâà honest, reliable and trustworthy. All the employees of the company with good will aim at high results, which improve quality of business itself and stuffs lifeÃâà (World Bank Group, 2009). Nowadays corruption and bureaucracy widespread among the business community and judiciary itself is subject to political interference and corruption (Adam Mycyk Elizabeth Cook, 2007 ). Conclusion to the chapter. An absence of progress in corporate governance in Ukraine can be explained by insufficiently deep character and consistency of institutional reforms realization.Ãâà The functioning of the new global economy is based on an effective management mechanism, implementation of the international accounting and audit standards and professional culture formation in corporate governance. In general, the corporate governance practices, which were adopted by Ukrainian companies, fail to reflect the high levels set byÃâà more developed European market economies and the United States. 5. Corporate governance in Germany 5.1 Introduction to the corporate governance system in Germany. History of corporate governance in Germany: In the 19th century, Germanys typical form of business organisation was the Kommanditgesellschaft (limited commercial partnership). A Kommanditgesellschaft always had at least one member with unlimited liability whereas the other investors liability was limited to their contribution. In 1861, the General Commercial Code was enacted which devoted a section to joint stock companies and allowed incorporations with limited liability. Companies could choose between a single board of directors and a two tiered board system, involving shareholders appointing a supervisory board, which in turn elected the management board. This changed in 1884 when a reform was introduced which mandated that companies have a two-tier board that allowed free registration without a system of state concession. Thus a supervisory board was needed to take over the states monitoring role. For members of the supervisory board it was not possible to be a member of the management board but it was possible for a share holder to directly elect member for the management board. In the early 20th century, formal acts of corporate law led to the abandonment of mercantilism and the rise of classical liberalism. Corporations increasingly became public and private entities free from government control. Under the Nazi government of Adolf Hitler then, companies became less democratic in a reform of 1937. From then on, shareholders could not elect managers directly, and managers could only be removed for an important reason, directors were elected for terms of five years and were under the duty to serve the Gemeinwohl or general good which was manifested by the state officials to be of higher priority than maximizing the companys revenues. After the war, new laws and changes all over the world led to more participation for workers within the corporations. Corporate Governance from 1980-2010 in general In the 1980s, many countries privatized large state-owned corporations. Deregulation reducing the regulation of corporate activity has often been accompanied by privatization and is part of the laissez-faire policy. Another major post-war shift caused the development of conglomerates, meaning that large corporations purchased smaller corporations to expand their industrial base. Especially more concentrated and owner-controlled firms had high returns during the 1970s and early 1980s but this turned in the late 1980s and1990s. Increasing international competition could be the cause. In the mid-1990s, Germany adopted a series of legal and regulatory reforms related to corporate governance. In 2002, the German Corporate Governance Code was created. The aim of the German Corporate Governance Code is to make Germanys corporate governance rules transparent for both national and international investors, thus strengthening confidence in the management of German corporations. The Code addresses all major criticisms especially from the international community levelled against German corporate governance, namely * inadequate focus on shareholder interests; * the two-tier system of executive board and supervisory board; * inadequate transparency of German corporate governance; * inadequate independence of German supervisory boards; * limited independence of financial statement auditors. Each of these five points is addressed in the provisions and stipulations of the Code, also taking into consideration the legal framework. Of course the Code cannot cover every detail of every single issue; instead it provides a framework which the individual companies will have to fill in. 5.2 Analysis of corporate governance in Germany from the approach of agency theory Corporate governance is about the way suppliers who finance corporations get a return from the managers on their investment. How can be ensured that managers do a good job and do not free-ride? How do suppliers of finance control the managers? These are principal-agent problems which have the essence that ownership and control or separation of management and finance are separated. Suppliers of finance give money to firms; the managers run the firm by using this supply of money and return some of the profit to the investors. Although this mechanism works out most of the time, the corporate governance problem is not yet solved. In Germany, a top manager even with poor performance is usually only removed after extreme circumstances as the boards are quite passive. There are large differences in legal protection of investors around the world. In Germany, at least some suppliers of finance have their rights protected and have them enforced by law through the courts, in contrast to many other countries. But still in Germany, managers are in most of the cases not liable. In Germany, over a quarter of all votes in major companies are controlled by large commercial banks. The banks also have smaller but still significant influence as direct shareholders or creditors. As studies estimate, do about 80% of the large German companies have a non-bank shareholder who owns a share of over 25%. Family control through majority ownership or pyramids is the norm in smaller German companies. A pyramid means that the owner controls 51% of the company which controls 51% of its subsidiaries. The function of pyramids is to enable the ultimate owners to control the assets with the least amount of capital. In Germany, large shareholders are associated with a higher turnover of directors. The effectiveness of large creditors and large shareholders depends on the legal rights they have. In Germany, banks have much power because they vote significant blocks of shares, sit on boards of directors, play a dominant role in lending and work in a legal environment favorable to creditors. In Germany, banking governance is very effective. German banks are relative to their lending power and control over equity votes not as active in corporate governance as one could expect. Large investors such as banks often fail to terminate unprofitable projects they have invested in when continuation is preferred to liquidation. A large investor often maximizes private benefits of control rather than wealth because he is rich enough. He will not internalize the costs of these control benefits to the other investors, large investors fail to force managers to maximize profits and pay them out. Germany has a successful corporate governance system relying on a combination of concentrated ownership and legal protection of investors. Compared to the United States, German creditors have stronger rights but shareholder rights are weaker. Germany has a system of governance by both permanent large shareholders, for whom the existing legal rules suffice to exercise their power, and by banks, but it does not have participation of small investors in the market. As Germany has a system of permanent large investors, hostile takeovers are rare. The advantage is that firms with long-term investors go through crises with less economic distress and better access to financing. Takeovers limit the planning for future for the managers and reduce the efficiency of investment. Permanent large shareholders and banks that dominate corporate governance in Germany are able to influence corporate management through informed investors who are better able to help firms. A large investor-oriented governance system discourages small investors from participating in financial markets. Germany has a successful corporate governance system that combines significant legal protection of at least investors with an important role for large investors. This combination is very different from the governance systems in most other countries which provide limited legal protection of investors and are stuck with family- and insider-dominated firms receiving little external financing. 5.3 Analysis of corporate governance in Germany from the approach of transaction costs theory The degree to which a firm can switch or differentiate its governance mechanisms depends on the legal jurisdiction in which it operates. German law accords greater bargaining power to labour unions than other countries do. This tends to create a stronger degree of governance inseparability. Governance inseparability means that a firms choice of governance mode for a transaction is constrained by the governance choices it made for prior transactions. Governance inseparability can also be created by contractual commitments. Most German firms are efficiently engaged in long-term exchange relationships which require long-term contractual commitments. These contractual commitments cause governance inseparability because they are costly and sometimes even impossible to reverse. The flexibility of a firm is restricted for the future through contractual commitments. Changes in bargaining power of other parties -e.g. employees, suppliers or customers to a firms contractual commitments can also lead to governance inseparability. Changes in bargaining power can for example emerge from changes in law and regulations. Parties that gained bargaining power unforeseen, try to use this circumstance to improve their own positions but forcing the firm to adopt locally suboptimal governance mechanisms in the future. The German government does not change its regulations constantly giving security to firms and private actors, but there are still other factors that could affect bargaining power and thus make changes in bargaining power to a constant risk in Germany. As German firms engage in long-term transactions, no firm can entirely avoid making contractual commitments and are thus always aware of the risk of governance inseparability. Governance inseparability constrains most firms over time because of their existing arrangements which limit their scope and flexibility. 5.4 Analysis of corporate governance in Germany from the approach of business ethics theory. Germans in general are pessimistic about the introduction of an ethical code. Businessmen in Germany think that ethical codes are not effective. In their view, ethical codes do not provide aid for executives in refusing unethical requests and do not give a clear definition of acceptable limits of conduct. But over the years, there is a growing acceptance of business ethics among German executives. Managers like former Nestl chairman Helmut Maucher, who are fed up with such moral poppycock have given way to an increasing number of corporate members of the German branch of the European Business Ethics Network, including well-known German companies, such as Daimler Benz, Bayerische Hypo Bank, Siemens, together with German subsidiaries of transnationals like Procter Gamble and IBM. 5.5 Conclusion to the chapter. The German corporate governance system is one of the best in the world. Of course it has some disadvantages and it still can be improved but it already works more efficient than most other corporate governance system and is one of the most advanced ones. Case study. Corporate governance in Ukraine and Germany differs in many ways. Ukrainian corporate governance system is younger and less developed, it has many weaknesses yet, comparing to the OECD standards of corporate governance and German Code of Corporate Governance (GCCG). This gap between the corporate governance systems in the two countries becomes especially obvious when globalization enters the picture. Due to the internationalization of the markets, foreign (German in our case) corporations with their own systems of corporate governance involve in the economy (Ukrainian in our case) with completely new to them conditions. Such changes have a double effect on both foreign corporations and domestic market. To show this, we will focus on how different are German corporations headquarters from their branches in Ukraine. 1). Metro AG was formed in Germany in 1996 through a merger of retail companies Asko Deutsche Kaufhaus AG, Kaufhof Holding AG and Deutsche SB-Kauf AG. The same year the company entered the list of 20 largest publicly listed companies in Germany and since then it started expanding to foreign markets as well. (Official website of METRO Group, https://www.metrogroup.de) METRO AG has established its branch in Ukraine in 2002. One of the main changes the company implemented was decentralization of its structure in order to improve performance of each separated sales division, this way METRO Cash Carry was formed in Ukraine. Further on METRO Cash Carry launched a new strategic performance improvement program MCC 2012 Committed to Excellence in Ukraine. The program is built upon two cornerstones: the re-positioning of METRO Cash Carrys business focus and the optimization of the companys structure with the introduction of a regional organization. METRO CashCarry Ukraine established an In ter-corporation university to provide practical managerial education to potential employees. (Official website of METRO CashCarry Ukraine, https://www.metro.ua) The company had to adjust to a number of particularities with regard to Ukrainian economy, political state and geographical specialties; weather conditions, different consumer preferences and available labour market supply were taken into consideration, and few alterations in the companys strategy, structure and logistics were made. A substantial problem was the process of negotiation in the beginning of business in Ukraine, the reason for that was lack of unity between the state national level authorities and city level authorities and inconsistency of their activity. Another substantial problem was caused by the difference in business ethics, written contracts are of the highest value in Ukraine, whereas METRO relies on the agreements with suppliers that regularly has contract proof, and therefore a number of trials on that account took place in Ukraine. As a matter of fact, METRO CashCarry was performing successfully in Ukrainian market, since they cooperate with mostly domestic suppliers, with national authorities and launch special projects for Ukrainian market, they employ national specialists as company managers, the company also focuses on the exchange of experience between the international branches and attempts to adjust the most to the country they operate in. 2). Henkel corporation has its headquarters in Dusseldorf, Germany. Henkel has business lines: Laundry Home Care, Cosmetics/Toiletries and Adhesive Technologies. The company management is committed to such principles: value creation as the foundation of our managerial approach; sustainability as a criterion for responsible management; transparency underpinned by an active and open information policy. Henkel corporation was established in Ukraine in 1998. The company is centrally managed, a range of products is not presented in Ukraine due to a lower level of demand for these products in Ukraine. The company succeed in Ukrainian market by employing Ukrainian specialists as top managers, although they would dedicate German specialists marketing and financial reporting functions, as the corporation required accounting to be done by its standards. Strong system of detailed planning for 5-years periods and experience of Ukrainian specialists in the domestic economy helped the company to get itself a strong position on the market. (Official website of Henkel corporation, https://www.henkel.ua/SID-AE091F88-63C2EB69/about-henkel-85.htm). Conclusion. 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